William Sheppard was born and raised in London, England to an Anglo-Irish family. He is a graduate of the Royal Academy of Dramatic Art in London. He was an Associate Artist with the Royal Shakespeare Company for 12 years. He appeared on Broadway in 1966 with "Marat-Sade" and later in 1975 with "Sherlock Holmes". He won the Los Angeles Drama Critics Circle award for "The Homecoming" in 1995, at the Matrix Theatre. He voiced the narrator in the popular computer game Civilization 5.